A study on implementation of WHO labour care guide in low-risk pregnant women and its impact on maternal and perinatal outcome

Background: WHO Labour Care Guide is a labour monitoring tool that is developed to support respectful maternity to provide positive childbirth experience with evidence-based recommendations.Methods: This is an observational study comparing WHO labour care guide with WHO modified partograph in low-risk pregnant women who are in active phase of labour. The study included 80 labouring women who are divided into two groups with 40 participants in each group. In group 1 WHO modified partograph was used and in group 2 WHO labour care guide was used as a tool to assess the course of labour. Maternal and perinatal outcomes were analysed for both the groups.Results: There is no significant difference in the caesarean section rates and instrumental deliveries between the two groups. There is a rise in the incidence of PPH and meconium-stained liquor in group 2 compared to group 1. None of the participants had labour beyond 12 hours. NICU admissions were higher in group 2.Conclusions: In our study, the WHO modified partograph was found as equivalent to WHO labour care guide in identifying prolonged labor. Also, maternal and perinatal outcomes were equally identified by both types of partograph. WHO labour care guide did not prove to be beneficial over WHO modified partograph in terms of maternal and perinatal outcomes in Indian parturient women

Improved Trial Division Algorithm by Lagrange?s Interpolation Function

Nowadays data communication over the internetgrowths the security risk on the side of receiver and transmitter. To reduce risk level, cryptography technique has been used which is based on aprivate and public key in disquiet of endorsement. The process of encryption and decryption improved the capacity of data security. Asymmetric cryptography technique provides renowned RSA public key cryptography technique. The success story of RSA algorithm depends on the prime factor. For the estimation of theprime factor used various mathematical functions. In this paper,Lagrange?s interpolation derivation for the estimation of aprime factoris used. The estimated prime factor is very complex and reduces the complexity of prime factor

Minimizing the Localization Error in Wireless Sensor Networks Using Multi-Objective Optimization Techniques

When it comes to remote sensing applications, wireless sensor networks (WSN) are crucial. Because of their small size, low cost, and ability to communicate with one another, sensors are finding more and more applications in a wide range of wireless technologies. The sensor network is the result of the fusion of microelectronic and electromechanical technologies. Through the localization procedure, the precise location of every network node can be determined. When trying to pinpoint the precise location of a node, a mobility anchor can be used in a helpful method known as mobility-assisted localization. In addition to improving route optimization for location-aware mobile nodes, the mobile anchor can do the same for stationary ones. This system proposes a multi-objective approach to minimizing the distance between the source and target nodes by employing the Dijkstra algorithm while avoiding obstacles. Both the Improved Grasshopper Optimization Algorithm (IGOA) and the Butterfly Optimization Algorithm (BOA) have been incorporated into multi-objective models for obstacle avoidance and route planning. Accuracy in localization is enhanced by the proposed system. Further, it decreases both localization errors and computation time when compared to the existing systems

Implementing Secure Group Communications using Key Graphs

While the technical issues of securing unicast communications for client-server computingare fairly well-understood, the technical issues of securing group communications are not. Theexisting approach to improve the scalability is to decompose a large group of clients into manysubgroups and employ a hierarchy of group security agents. In this paper, the secure groupcommunications using key graphs and the implementation of a different hierarchical approachto improve the scalability and secure group communication using key graphs has been presented

A PRIVACY BASED ACCESS MANAGING SYSTEM IN CLOUD BASED SERVICES

Cipher text-Policy ABE (Clubpenguin-ABE) is resourcefully designed meant for outburst direct important cyphered data. It's one among the primary appropriate technologies meant for controlling of sense accessibility within cloud storage systems, for it threaten the data proprieties remanent direct control above accessibility policies. The revocable several-government CPABE can be a comprehensive technique, which may be functional in almost any faint storing systems furthermore to online social systems. We yield a revocable plot of multiauthority Clubpenguin-ABE structure that may nurture large attribute revocation. Our plan doesn't necessitate server to possess completely authentic, since forelock update is enforced by every reputation witness not server. Even though the server isn't demi--reliable in a number of scenarios, our schemes could impudence backward security and additionally devise structure is well-organized and gain less account outlay, that's unendangered and accomplishes ago assurance furthermore to earnest security. Within our novel attribute revocation method, only ciphertexts which are associated with repress attribute must be modernized

EVALUATION OF THE PROPHYLACTIC ROLE OF INDIAN SHRIMP IN ALUMINUM CHLORIDE-INDUCED ALZHEIMER’S DISEASE ON EXPERIMENTAL RATS

Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats. Methods: The male Wistar rats were selected and divided into six groups. Group I received distilled water, Group II received AlCl3 ( 100 mg/kg, p.o.), Group III received rivastigmine (1 mg/kg, p.o.), Group IV received AlCl3 + shrimp powder (200 mg/kg, p.o), and Group V received AlCl3 + shrimp powder (400 mg/kg, p.o) for 60 days. At the end of the study, various parameters such as behavioral and biochemical investigations were assessed. Results: The result of the study shows that the shrimp (400 mg/kg) has better effect on the treatment of aluminum chloride-induced AD in rats. It showed a remarkable improvement in the behavioral and biochemical parameters, and the result of histopathology study shows that the hippocampus region of brain tissue recovered as compared with control. Conclusion: From this study, it is evident that dietary intake of shrimp can help to inhibit oxidative stress produced due to the accumulation of AlCl3 in the brain and used as a prophylactic for AD

FORMULATION AND DEVELOPMENT OF MICROSPHERES FOR THE TREATMENT OF FAMILIAL ADENOMATOUS POLYPOSIS

Objective: Familial adenomatous polyposis (FAP) also known as familial polyposis coli, is a hereditary disease characterized by progressive appearance of numerous polyps mainly in the large intestine. Polyps are initially benign but can easily become cancerous and as such it is a life threatening condition. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor is thought to induce cell death, and thus prevent or delay the growth of polyps. So in the present study celecoxib loaded microspheres were prepared using control release Hydroxy propyl methyl cellulose (HPMC K4M) and pH dependent polymer eudragit L 100-55 in different ratios (1:1 to 1:4) respectively. The main objective of the study is to identify the polymer concentration required to prevent the drug release in stomach region and promotes in intestinal region.Methods: Emulsification solvent evaporation method was selected for the preparation and all the optimized formulations were evaluated for drug-polymer interactions, percentage yield, micrometric properties, entrapment efficiency, particle size analysis, differential scanning calorimetry and in vitro dissolution study.Results: Drug and polymer interactions were evaluated by using FTIR and DSC. The FTIR spectrum and DSC thermograms stated that drug and polymer are compatible to each other. The micrometric properties of drug loaded microspheres were carried out and they were found to be as the angle of repose (18.26 °-40.69 °), bulk density (0.2846-0.3875), tapped density (0.4111-0.5428), Carr's index (9.66-14.77), Hausner's ratio (1.112-1.2642) which were within the limits. In vitro dissolution, drug release was found to be from 4.5 to 6.5 h for the prepared four formulations (F1–F4). From the kinetic data modeling the order of drug release was found to be zero order and korsmeyer-peppas with n value above 0.5 for all the formulations indicating non-fickian diffusion.Conclusion: All the result demonstrated that celecoxib microspheres can be effectively used in the treatment of familial adenomatous polyposi

Patterns of epithelial cell abnormalities in Pap smears and its clinicopathological and demographic association: a descriptive study from Visakhapatnam city, Andhra Pradesh, India

Background: Cervical cancer is one of the leading cancers amongst women. Periodic pap screening is the simplest way to diagnose precancerous lesions. Factors such as ignorance, poverty poorly developed public healthcare delivery system put women in urban slums at a disadvantage for receiving any health screening activity. Objectives of the present study were to know the prevalence of epithelial cell abnormalities of the cervix among the subjects and to study the association with clinical and demographic characteristics.Methods: A camp based descriptive study was conducted in an urban ward. All women above the age of 20 years were included in the study. Data was recorded using a pretested questionnaire. Study variables included socio-demographic characteristics, symptoms of reproductive tract infection, findings of clinical examination, and Pap smear collection and evaluation. The latter was done from 194 women aged between 20-69 years. Pap smears were made by conventional Pap smear technique and reported according to The Revised Bethesda System of classification 2001(TBS).Results: Among the 194 women, in 8 subjects, the smears collected were unsatisfactory for evaluation. Analysis was done in the remaining 186 subjects. Among the latter, in 83.9%, the smears were negative for intraepithelial lesions (NIEL) and 16.1% revealed epithelial cell abnormalities (ECA). Among those with ECA, Atypical cells of undetermined significance (ASCUS) was identified in 66.67%, Low grade squamous intraepithelial lesions(LSIL) in 16.67%, Atypical squamous cells-cannot exclude HSIL (ASC-H) and Atypical glandular cells-not otherwise specified (AGC-NOS) in 6.67% each and High grade squamous intraepithelial lesions (HSIL) in 3.33%. Epithelial cell abnormalities were more common in women in the age group of 30-60 years (80%), they were more common in those with age at marriage between 13-18 years (63.3%) and in those with age at first child birth between 15-19 years (56.7%). Conclusions: Therefore there is a need for Pap screening at regular intervals through camp based approach in these populations to motivate the women, increase their awareness, ensure follow up and referral and timely intervention in appropriate cases.

Evaluation of clinical outcomes in neuropathic pain with combinations of anti-neuropathic drugs

Background: Much of the pharmacological treatment modalities especially individual drugs for treating neuropathic pain have unwanted side effects, multiple day to day dosing, modest efficacy of topical treatments, and their local side effects. Combination drug regimen has the advantage of offering relatively better pain relief at lower drug doses and lesser side effects.Methods: The study was conducted in the Department of Neurology at NRI General Hospital, Guntur. The patients who met the inclusion and exclusion criteria were enrolled and assigned into 3 groups of the study drug combinations. The baseline characteristics and post interventional scores of Toronto Clinical Scoring System (TCSS), visual analogue scale (VAS), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D) and Medical outcome of sleep scale (MOS) and were analyzed using t test and mean difference.Results: A statistically significant reduction in neuropathic pain in all the three groups was found. The mean difference between the baseline and post interventional scores of TCSS and VAS of group I, II and III were 2.97, 2.75, and 1.97; 2.32, 1.12, and 0.95 respectively. There was a statistically significant improvement of HAM-A in all the three groups, HAM-D and MOS sleep scale were found significant only in group II.Conclusions: The study findings revealed that all the three drug combinations were effective in the management of neuropathic pain with pregabalin and oxcarbazepine combination being better with respect to efficacy and tolerability. Regarding the treatment of depression and sleep disturbances associated with NP pregabalin and duloxetine was more effective

Comparison of CD3 and CD8 immunoscoring with histological grade of the tumor in urothelial carcinoma of bladder

Background: Inflammatory response within transitional cell carcinoma (TCC) bladder is known to be predictive of tumor prognosis. Lower scores are associated with worser outcome and vice versa. Simpler and cost-effective methods of immunoscoring using immunohistochemistry (IHC) have been described. This study uses two easily available T-cell markers CD3 and CD8 and compares their immunoscore with tumor grade and understands the association. Aims and Objectives: The aims of this study were as follows: (1) To perform immunoscoring for cytotoxic T lymphocytes -CD3+ and CD8+ lymphocytes in urothelial carcinoma and (2) to correlate the immunoscore with tumor grade and calculate its significance in predicting prognosis. Materials and Methods: A prospective cross-sectional study of 2 years duration from October 2018 to October 2020 was conducted at a tertiary level super specialty government institution. All the transurethral resection of bladder tissue biopsies reported as urothelial malignancies during the study period were included in the research. The tumors were graded histologically into high grade and low grade on histology based on the World Health Organization 2016 classification of Urothelial Carcinomas/International Society of Urological Pathology grading system. They were then subject to IHC with two T-cell markers CD3 and CD8 and immunoscoring was done using the method described by Galon. Results: A total of 42 cases of urothelial malignancies were diagnosed during the study period. Cases with higher tumor grade were 25 and lower tumor grade were 17. The association between the lower immunoscore and higher tumor grade was statistically significant. Conclusion: Immunoscoring is a useful adjunct to the routine histological evaluation of TCC. Easily available T-cell markers can be used as simple easy and cost-effective method for immunoscoring